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首页 经销厂牌 Creative Biolabs Premade Human Antibody Library for Yeast Display

Premade Human Antibody Library for Yeast Display

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Scientists in Creative Biolabs have constructed a series of high quality yeast surface-displayed human antibody libraries for de novo discovery of therapeutically relevant antibodies. They’re available for license or contract service.

Table 1: Premade Human Antibody Libraries

Catalog #Type Ab FormatSize# DonorNote
HuscL-YDP-1®naïve scFv∼101156 donorsN/A
HuscL-YDP-2®naïve scFv∼109200 donorsN/A
Custom HuscL-YDP-3®naïve scFv∼101156 donorsEnriched in scFv of client’s interest
HuscL-YDP-4®naïvescFv2× 10660 donorsIt's an anti-DR5 pseudo-immune human single-chain fragment variable (scFv) library on the yeast cell surface.
HuscL-YDP-5®naïve scFv∼10958 donorsN/A
HuscL-YDP-6®naïve scFv1.4× 1010N/AN/A
HuscL-YDP-7®imumunescFv∼1091 donorGene for this library is isolated from the bone marrow mononuclear cell of an HIV-infected donor who exhibits broad serum neutralization of HIV-1.
HuFabL-YDP-1®naïve Fab over 10935 donorsThe human LC and HC cDNAs were
harvested from a pool of 35 autoimmune patients.
HuFabL-YDP-2®syntheticFab1.2 × 109N/AIt's a yeast surface-displayed combinatorial  Fab-1 with 11 CDR-H3 residues library.
HuFabL-YDP-3®syntheticFab1.1 × 109N/AIt's a yeast surface-displayed combinatorial  Fab-2 with 9CDR-H3 residues.
HuscFabL-YDP-1®imumunescFab∼1091 donorGene for this library is isolated from the bone marrow mononuclear cell of an HIV-infected donor who exhibits broad serum neutralization of HIV-1.
HuIgGL-YDP-1®naïve full-length IgG1.5 × 109N/AThis full-length IgG yeast  surface-displayed library is constructed without requiring a genetically encoded anchor protein or intracellular antibody modification.
HuIgGL-YDP-2®naïve full-length IgG∼109150 donorsN/A
HuFn3L-YDP-1®naïve Fn36.5 × 107N/AFn3 refers to the 10th type III domain of human fibronectin.

These libraries have a size ranging from 106 to 1011 and cover most commonly used antibody formats, including scFv, Fab, scFab, full-length IgG and Fn3. Comprehensive library types and various genetic backgrounds give these libraries multiple functions and applications. In combination with the Ultraff™ Yeast Display Technology or Yeast Mating Technology from Creative Biolabs, low nanomolar, even picomolar-affinity antibodies of different formats are routinely obtained. All human antibody libraries for yeast display licensed from Creative Biolabs can be amplified 1010 fold under proper operation, without measurable loss of clonal diversity, allowing effectively indefinite expansion. Creative Biolabs’ top quality human antibody libraries for yeast display can improve your results and save your time in novel antibody discovery.

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Advantages of Yeast Display:

  • Eukaryotic expression and processing
  • Quality control mechanisms of the eukaryotic secretary pathway
  • Minimal avidity effects
  • Quantitative library screening through FACS
  • Complex post-translational modifications

For license or contract service, please Contact Us.

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