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Metabolism

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Metabolism is a vital process for all life forms. It is broadly defined as the sum of all the biochemical processes involved in maintaining the living state of the cells, and thus the organism. More than 87,000 reactions & 16,000 metabolites are annotated in the Kyoto Encyclopedia of genes & genome. Transformation of the macronutrients such as carbohydrates, proteins, and fats in food to energy is an integral part of the metabolic processes. Metabolic processes can be divided into two main categories: anabolic processes, which consume energy to synthesize simple molecules or polymerize them into more complex macromolecules e.g. DNA, RNA and proteins and catabolic processes that degrade molecules to release energy. Besides this, metabolic processes also help to get rid of toxic substances.

Metabolism plays a key role in disparate areas of physiology, cell biology, and medicine. Research in metabolism is dramatically increased by the realization that many common human diseases such as cancer, diabetes, obesity, hypoglycemia, hypolipidemia, phenylketonuria, neurodegeneration etc. are due to perturbations in metabolic pathways. Understanding the metabolic variations and possible outliers is thus a crucial aspect of disease-oriented research.

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