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首页 经销厂牌 Creative Biolabs Premade Phage Display Antibody Libraries

Premade Phage Display Antibody Libraries

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Creative Biolabs is an undisputed world-leading service provider and research institution in phage display library technique. We offer following world-class premade human and mouse antibody libraries with great capacity & diversity that can derive highly specific, high affinity antibodies ranging from 10 pM to 10 nM.

During the past decades, we have integrated a comprehensive portfolio of premade antibody libraries, including human scFv librarieshuman Fab librariesmouse scFv/Fab librariesrabbit Fab librarieschicken scFv libraries and single domain antibody libraries. We also offer multiple high-quality premade antibody libraries for yeast display.

HuScL-2: Human Single Chain Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and c-Myc detection tag
  3. VH-VL format scFv library
  4. Human antibody genes from semi-synthesis
  5. Capacity: 1.42×109
  6. Proliferation in TG1 cells
  7. Production of soluble antibody fragments in HB2151
  8. Helper phage KM13

HuScL-3: Human Single Chain Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and V5 detection tags
  3. VH-VL format scFv library
  4. Collections of human antibody genes from non-immunized donors
  5. VL/VH chain recombination through an integrated Cre/lox system
  6. Capacity: 1.6×109
  7. Proliferation in TG1 cells
  8. Production of soluble antibody fragments in HB2151
  9. Helper phage M13KO7

HuScL-4: Human Single Chain (scFv) Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing a FLAG and 6xHis tag
  3. VH-VL format scFv library
  4. Collections of human antibody genes from non-immunized donors
  5. Capacity: 2.0×109
  6. Production of soluble antibody fragments in HB2151
  7. Helper phage M13KO7

HuScL-5: Human Synthetic scFv Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and c-Myc detection tags
  3. VH-VL format scFv library
  4. 7 heavy chain frameworks and 7 light chain frameworks representing the structural diversity of human antibody repertoire (based on analysis of more than 200 scFv sequences)
  5. Complete randomization in HCDR3 and LCDR3
  6. Theoretic capacity: 2.0×1010
  7. Proliferation in TG1 cells
  8. Production of soluble antibody fragments in HB2151
  9. Helper phage M13KO7

HuScL-2S: Human Synthetic Single Chain Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and c-Myc detection tag
  3. VH-VL format scFv library
  4. Human antibody genes derived from semi-synthesis (selectively mutated 18-26 residues among all 6 CDRs)
  5. Capacity: 2.36×1010
  6. Proliferation in TG1 cells
  7. Production of soluble antibody fragments in HB2151
  8. Helper phage KM13 or M13K07

HuFabL-1: Human Fab Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and c-Myc detection tag
  3. Fab format
  4. Collections of human antibody genes from non-immunized donors
  5. Capacity: 2.0×109
  6. Proliferation in TG1 cells
  7. Production of soluble antibody fragments in HB2151
  8. Helper phage M13K07

HuFabL-2: Human Naïve & Semi-synthetic Fab Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and c-Myc detection tag
  3. Fab format
  4. Collections of human Fab V genes from non-immunized donors
  5. Introduced randomization in heavy chain CDR1 and CDR2
  6. Capacity: 2.0×1010
  7. Proliferation in TG1 cells
  8. Production of soluble antibody fragments in HB2151
  9. Helper phage M13K07

HuFabL-3: Human Naïve Fab Library

We have recently established a novel human naïve Fab library with unparalleled quality. Preliminary validation results revealed excellent insert efficiency, sequence diversity and biopanning output:

  1. Phagemid phage display system
  2. M13 pIII fusion containing short 6xHis and c-Myc detection tag
  3. Fab format
  4. Collections of human antibody genes from non-immunized donors
  5. Capacity: 4.29×109
  6. Proliferation in SS320 cells
  7. Helper phage VSCM13

Besides, we are currently working on construction and validation of several Fab synthetic libraries using Trimer Codon technology, which have natural diversity and favorable biophysical properties.

MuScL-1: Murine Single Chain Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion
  3. scFv format
  4. Collections of antibody genes from none immunized mice
  5. Capacity: 8.0×108

MuFabL-1: Murine Fab Antibody Library

  1. Phagemid phage display system
  2. M13 gIII fusion
  3. Fab format
  4. Collections of antibody genes from naive mice
  5. Capacity: 6.0×109

RaFabL: Rabbit Naïve Fab Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short a 6xHis and HA detection tag
  3. Fab format
  4. Collections of antibody genes from none immunized rabbits
  5. Capacity: 7.5×109
  6. Proliferation in TG1 cells
  7. Helper phage M13K07

Chicken-ScL: Chicken Naïve scFv Antibody Library

  1. Phagemid phage display system
  2. M13 pIII fusion containing short a 6xHis and Myc detection tag
  3. scFv format
  4. Collections of antibody genes from none immunized chicken lymphocytes
  5. Capacity: 1.2×109
  6. Proliferation in TG1 cells
  7. Production of soluble antibody fragments in HB2151
  8. Helper phage M13K07

Giving these appealing features, premade human antibody screening manifest as an all-powerful solution to various therapeutic/diagnostic antibody development programs. A large number of reputable references are available, for whom we have generated good human antibodies for therapeutic application using these human antibody libraries. Quite a few of our customers have moved their antibody candidates into preclinical studies and clinical trials. Besides, we are also glad to provide one-stop custom service of premade library screening against various targets. Please feel free to inquire us for more information.




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